2021年

2021年所發表的論文  (* Corresponding Author)

  1. Chao CC, Shen PW, Tzeng TY(曾才郁), Kung HJ, Tsai TF, Wong YH. Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging.2021; Biomedicines 9(11)1635
  2. Tsai, C.Y., Chen, C.T., Lin, C.H(林芩卉)., Liao, C.C., Hua, K(花嘉玲)., Hsu, C.H., and Chen, C.F(陳建鋒). Proteomic analysis of Exosomes derived from the Aqueous Humor of Myopia Patients. International Journal of Medical Sciences 2021; 18(9)2023-20292.    
  3. Huang, Y.F., Chang, C.H., Chen, P.J., Lin, I.H., Tsai, Y.A., Chen, C.F(陳建鋒)., Wang, Y.C., Huang, W.Y., Tsai, M.S., and Chen, M.L. Prenatal Bisphenol a Exposure, DNA Methylation, and Low Birth Weight: A Pilot Study in Taiwan. International Journal of Environmental Research and Public Health 2021; 18(11)6144
  4. Chang, C.H., Yu, C.J., Du, J.C., Chiou, H.C., Hou, J.W., Yang, W., Chen, C.F(陳建鋒)., Chen, H.C., Chen, Y.S., Hwang, B., and Chen, M.L. The associations among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of paraoxonases in children with attention deficit/hyperactivity disorder. International Journal of Medical Sciences 2021; 733;145604
  5. W.W. Yeh, M. Campbell, L. Chang, P.C. Chang(張佩靖). Long non-coding RNA KIKAT/LINC01061 as a novel epigenetic regulator that relocates KDM4A on chromatin and modulates viral reactivation. PLoS Pathogens 2021; 17(6) e1009670
  6. Liao TT, Cheng WC, Yang CY, Chen YQ(陳胤全), Su SH, Yeh TY, Lan HY, Lee CC, Lin HH, Lin CC, Lu RH, Chiou ET, Jiang JK*, Hwang WL(黃尉倫)* The microRNA-210-stathmin1 axis decreases cell stiffness to facilitate the invasiveness of colorectal cancer stem cells. Cancers 2021;13(8)
  7. Fitriana Melysa †, Hwang WL(黃尉倫)*, Chan PY, Hsueh TY and Liao TT. Roles of microRNAs in regulating cancer stemness in head and neck cancers. Cancers 2021;13(7)
  8. Hung-Ming Chen, Chun-Chi Lin, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Shih-Ching Chang, Ching-Liang Ho, Chung-Chi Yang, Shih-Ching Huang, Yee Chao, Tsai-Tsen Liao, Wei-Lun Hwang(黃尉倫)* and Hao-Wei Teng*. Insulin-Like growth factor 2 mRNA-binding protein 1 (IGF2BP1) Is a prognostic biomarker and associated with chemotherapy responsiveness in colorectal cancer. Int J Mol Sci. 2021;22(13)
  9. Wei-Kuang Yu, Wei-Lun Hwang(黃尉倫), Yi-Chuan Wang, Chieh-Chih Tsai* and Yau-Huei Wei*. Curcumin suppresses TGF-β1-induced myofibroblast differentiation and attenuates angiogenic activity of orbital fibroblasts. Int J Mol Sci 2021;22(13)
  10. Lee HH†, Wang YN†, Yang WH†, Xia W, Wei YK , Chan LC, Wang YH, Jiang Z, Xu SP , Yao J , Qiu YF, Hsu YH, Hwang WL(黃尉倫), Yan MS , Cha JH , Hsu Jennifer , Shen J , Ye Y, Wu X , Hou MF , Tseng LM , Wang SC , Pan MR , Yang CH , Wang YL , Yamaguchi H, Pang D , Hortobagyi G, Yu Dihua, Hung MC*.Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun.2021;12(1)
  11. Yu-Ling Lee, Keiichi Ito, Wen-Chieh Pi, I-Hsuan Lin, Chi-Shuen Chu, Sohail Malik, I-Hsin Cheng, Wei-Yi Chen(陳威儀)*, and  Robert G. Roeder* .Mediator subunit MED1 is required for E2A-PBX1-mediated oncogenic transcription and leukemic cell growth. Proceedings of the National Academy of Sciences of the United States of America 2021;118(6) e1922864118
  12. Yu-Ting Huang, An-Chieh Cheng, Hui-Chi Tang, Guo-Cheng Huang, Ling Cai, Ta-Hsien Lin, Kou-Juey Wu, Ping-Hui Tseng, Greg G Wang, Wei-Yi Chen(陳威儀). USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer. Cell Death and Disease 2021;12(10)880
  13. Ching-Tung Chu(褚璟彤) , Yi-Hsuan Chen , Wen-Tai Chiu , Hong-Chen Che(陳鴻震). Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase. Life Science Alliance 2021;4(10)1-16
  14. Wei YF, Sheu CC, Wang CY, Hsu CK, Chen CM, Chen WC, Yang KY(陽光耀)*.. Effect of tiotropium soft mist inhalers on dynamic changes in lung mechanics of patients with chronic obstructive pulmonary disease receiving mechanical ventilation: a prospective pilot study. Pharmaceutics 2021;13(1)51
  15. Perng CK, Sheu CC, Lin YC, Chan MC, Wang SH, Chen CM, Shen YC, Zheng ZR, Lin YT, Yang KY(陽光耀)*. Efficacy of adjunctive nebulized colistin in critically ill patients with nosocomial carbapenem-resistant gram-negative bacterial pneumonia: a multi-centre observational study. Clin Microbiol Infect 2021;27(10)1465-1473
  16. Lemiale V, Rathi N, Cortegiani A, Pène F, Bonny V, Salluh J, Albaiceta GM, Soares M, Soubani AO, Canet E, Hanane T, Kouatchet A, Mokart D, Lebiedz P, Türkoğlu M, Coudroy R, Jeon K, Demoule A, Mehta S, Caruso P, Frat JP, Yang KY(陽光耀), Roca O, Laffey J, Timsit JF, Azoulay E, Darmon M. Survival in immunocompromised patients ultimately requiring invasive mechanical ventilation: a pooled individual patient data analysis. Am J Respir Crit Care Med 2021;204(2)187-196
  17. Leu SW, Lin SW, Liang SJ, Yang KY(陽光耀), Chan MC, Chen WC, Hu HC, Fang WF, Chen YM, Sheu CC, Tsai MJ, Wang HC, Chien YC, Peng CK, Wu CL, Kao KC. Renal replacement therapy in patients with influenza pneumonia related acute respiratory distress syndrome. J Clin Med 2021;10(9)1837
  18. Chiou SH, Chen WC, Yu WK, Wu HH, Chen H, Yang KY(陽光耀). iPSC-derived conditioned medium promotes endogenous LIF to attenuate endotoxin-induced ALI. Int J Mol Sci 2021;22(11)5554
  19. Lee YT, Pan SW, Yang KY(陽光耀), Chen YM, Yen DH, Li SY, Wang FD. Comparison of colistin-induced nephrotoxicity between two different formulations of colistin in critically ill patients: a retrospective cohort study. Antimicrob Resist Infect Control 2021;10(1)111
  20. Yang KY Yang KY(陽光耀)., Sheu CC, Chen WC, Chan MC, Feng JY, Chen CM, Wu BR,  Zheng ZR, Chou YC, Peng CK. Efficacies of colistin-carbapenem versus colistin-tigecycline in critically ill patients with CR-GNB associated pneumonia: a multicenter observational study. Antibiotics 2021;10(9)1081
  21. Chen WC, Yu WK, Wu HH, Chen H, Yang KY(陽光耀). Nintedanib regulates GRK2 and CXCR2 to reduce neutrophil recruitment in endotoxin-induced lung injury. Int J Mol Sci 2021;22(18)9898
  22. Yu WK, Pan SW, Chen WC, Yang KY(陽光耀), Lin YT, Wang FD, Yang MH, Chen YM. Consensus statement and recommendations on the treatment of COVID-19: 2021 update. J Chin Med Assoc 2021; Online ahead of print
  23. Hu HC, Chiu LC, Chan MC, Liang SJ, YangKY(陽光耀), Chen W, Fang WF, Chen YM, Sheu CC, Chang WA, Wang HC, Chien YC, Peng CK, Wu CL, Kao KC, TSIRC. Comparison of prone positioning and extracorporeal membrane oxygenation in acute respiratory distress syndrome: A multicenter cohort study and propensity-matched analysis. J Formos Med Assoc 2021; Online ahead of print
  24. Lan, S. H(藍昇輝)., S. C. Lin, W. C. Wang, Y. C. Yang, J. C. Lee, P. W. Lin, M. L. Chu, K. Y. Lan, R. Zuchini, H. S. Liu and S. Y. Wu. Autophagy Upregulates miR-449a Expression to Suppress Progression of Colorectal Cancer. Front Oncol 2021;11, 738144
  25. Wu, S. Y., Y. L. Chen, Y. R. Lee, C. F. Lin, S. H. Lan(藍昇輝), K. Y. Lan, M. L. Chu, P. W. Lin, Z. L. Yang, Y. H. Chen, W. H. Wang and H. S. Liu. The Autophagosomes Containing Dengue Virus Proteins and Full-Length Genomic RNA Are Infectious. Viruses 2021;13(10)
  26. Chi-Chin Sun, Shao-Yun Lee, Cheng-Heng Kao, Li-Hsien Chen, Zhao-Qing Shen, Chia-Hui Lai, Tsai-Yu Tzeng(曾才郁), Jong-Hwei Su Pang, Wen-Tai Chiu, Ting-Fen Tsai. Cisd2 plays an essential role in corneal epithelial regeneration. EBioMedicine 2021;73, 103654
  27. Szu-Ting Chen(陳斯婷), Babamale Olarewaju Abdulkareem. Nod-Like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections. Int. J. Mol. Sci. 2021;22(21)11398-11428
  28. Cheng-Han Tsai, Chun-Yuan Chang, Bing-Ze Lin, Yu-Lou Wu, Meng-Hsiu Wu, Liang-Ting Lin, Wen-Chien Huang, Jonathan D. Holz, Tzong-Jen Sheu, Jhih-Shian Lee, Richard N. Kitsis, Pei-Han Tai, Yi-Jang Lee(李易展). Up-regulation of cofilin-1 in cell senescence associates with morphological change and p27kip1 mediated growth delay. Aging Cell 2021;20
  29. Shan-Ying Wang, Liang-Ting Lin, Bing-Ze Lin, Chi-Hsien Chang, Chun-Yuan Chang, Min-Ying Lin, Yi-Jang Lee(李易展). A Comparative Study of Single or Dual Treatment of Theranostic 188Re-Liposome on MicroRNA Expressive Profiles of Orthotopic Human Head and Neck Tumor Model. Heighpubs Otolaryngology and Rhinology 2021;5
  30. Yi-Xuan Li, Shih-Po Su, Chou-Hsun Yang, Ming-Ho Liu, Pin-Ho Lo, Yi-Chen Chen, Chao-Ping Hsu, Yi-Jang Lee(李易展), Huihua Kenny Chiang, Yang-Hsiang Chan. Molecular Design of Ultrabright Semiconducting Polymer Dots with High NIR-II Fluorescence for 3D Tumor Mapping. Advanced Healthcare Materials 2021;21
  31. Min-Ying Lin, Hsin-Hua Hsieh, Jyh-Cheng Chen, Chuan-Lin Chen, Nin-Chu Sheu, Wen-Sheng Huang, Shinn-Ying Ho, Ting-Wen Chen, Yi-Jang Lee(李易展) *, Chun-Yi Wu * Brachytherapy Approach Using 177Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model. Pharmaceutics 2021;13
  32. Min-Ying Lin, Hsin-Hua Hsieh, Jyh-Cheng Chen, Chuan-Lin Chen, Nin-Chu Sheu, Wen-Sheng Huang, Shinn-Ying Ho, Ting-Wen Chen, Yi-Jang Lee(李易展) *, Chun-Yi Wu *. OncomiR miR-182-5p enhances radiosensitivity by inhibiting the radiation-induced antioxidant effect through SESN2 in head and neck cancer. Antioxidants 2021;10
  33. Jyh-Der Leu, Chung-Yih Wang, Chia-Chen Lo, Min-Ying Lin, Chun-Yuan Chang, Wen-Chin Hung, Shi-Ting Lin, Bo-Shen Wang, and Yi-Jang Lee(李易展). Involvement of c-Myc in low dose radiation-induced senescence enhanced migration and invasion of unirradiated cancer cells. Aging 2021;13
  34. Ali A, Kuo WW, Kuo CH, Lo JF(羅正汎), Chen MYC, Daddam JR, Ho TJ, Viswanadha VP, Shibu MA, Huang CY. E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton’s jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages. Bioeng Transl Med. 2021;6(3) e10234.
  35. Chen MC, Hsu LL, Wang SF, Pan YL, Lo JF(羅正汎), Yeh TS, Tseng LM, Lee HC.Salubrinal Enhances Cancer Cell Death during Glucose Deprivation through the Upregulation of xCT and Mitochondrial Oxidative Stress. Biomedicines. 2021;9(9)1101
  36. Chang CY, Wei CY, Chen PH, Hou MC, Chao Y, Chau GY, Lee RC, Huang YH, Su YH, Wu JC(吳肇卿), Su CW*(corresponding author). The role of albumin-bilirubin grade in determining the outcomes of patients with very early stage hepatocellular carcinoma. The role of albumin-bilirubin grade in determining the outcomes of patients with very early stage hepatocellular carcinoma. Journal of the Chinese Medical Association 2021;84(2)136-143
  37. Liang YJ (梁毓津), Teng W, Teng RD, Sun CP, Huang YH, Liang KH, Chen YW, Chen CL, Su CW, Lin CC, Tao MH, Wu JC(吳肇卿)*. Clinical implications on HBV preS/S mutations and the effects of preS2 deletion on mitochondria, liver fibrosis, and cancer development. Herpetology 2021;74(2)641-655
  38. Lin HH, Hsu SJ, Lu SN, Chuang WL, Hsu CW, Chien RN, Yang SS, Su WW,†† Wu JC (吳肇卿), Lee TH, Peng CY, Tseng KC, Qin A, Huang YW, Chen PJ. Ropeginterferon alfa-2b in patients with genotype 1 chronic hepatitis C: Pharmacokinetics, safety, and preliminary efficacy. Journal of Gastroenterology and Hepatology 2021;5(8)929-940
  39. Chang TE, Su CW*, Huang YS, Huang YH, Hou MC, Wu JC(吳肇卿)* Hepatitis D virus dual infection increased the risk of hepatocellular carcinoma compared to hepatitis B virus mono infection: a meta-analysis. Journal of the Chinese Medical Association 2021
  40. Teng W, Chang TT, Yang HI, Peng CY, Su CW, Su TH7, Hu TH, Yu ML, Yang HC, Wu JC(吳肇卿)*. Risk scores to predict HCC and the benefits of antiviral therapy for CHB patients in gray zone of treatment guideline. Hepatology international 2021; Epub ahead of print.
  41. Tyn+D45:D48g-An Zhou, Hsuan-Po Hsu, Yueh-Hua Tu, Chih-Yu Lin, Nien-Jung Chen, Jin-Wu Tsai, Ellen A. Robey, Hsuan-Cheng Huang, Chia-Lin Hsu(徐嘉琳), and Ivan L. Dzhagalov. Thymic macrophages consist of two populations with distinct2 localization and origin. bioRxiv 2021
  42. Hsuan-Po Hsu, Yun-Tzu Chen, Yu-Ying Chen, Chih-Yu Lin, Po-Yu Chen, Shio-Yi Liao, Ciara Christianne Y. Lim, Yu Yamaguchi, Chia-Lin Hsu(徐嘉琳), Ivan L. Dzhagalov. Heparan sulfate is essential for thymus growth. Journal of Biological Chemistry 2021;21,192-197
  43. Jong-Wei Lin , Yi-Man Huang , Yin-Quan Chen(陳胤全) , Ting-Yun Chuang , Tien-Yun Lan 1, Yen-Wenn Liu , Hung-Wei Pan , Li-Ru You(游麗如) 1, Yang-Kao Wang , Keng-Hui Lin , Arthur Chiou , Jean-Cheng Kuo (郭津岑). Dexamethasone accelerates muscle regeneration by modulating kinesin-1-mediated focal adhesion signals. Cell Death Discovery 2021;7(1)35
  44. Ishola AA, Chien CS, Yang YP, Chien Y, Yarmishyn AA, Tsai PH, Chen JC, Hsu PK, Luo YH, Chen YM, Liang KH, Lan YT, Huo TI, Ma HI, Chen MT, Wang ML, Chiou SH(邱士華). Oncogenic circRNA hsa_circ_0000190 modulates EGFR/ERK pathway in promoting NSCLC. Cancer Research 2021; accepted
  45. Hsiao BY, Chen CH, Chi HY, Yen PR, Yu YZ, Lin CH, Pang TL, Lin WC, Li ML, Yeh YC, Chou TY(周德盈), Chen MY(陳美瑜). Human Costars Family Protein ABRACL Modulates Actin Dynamics and Cell Migration and Associates with Tumorigenic Growth. International journal of molecular sciences 2021;22(4)2037
  46. Wang LC, Lin TC, Yeh YC, Ho HL, Tsai CC, Chou TY(周德盈). Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents. Current oncology 2021;28(1)918-927
  47. Mino-Kenudson M, Le Stang N, Daigneault JB, Nicholson AG, Cooper WA, Roden AC, Moreira AL, Thunnissen E, Papotti M, Pelosi G, Motoi N, Poleri C, Brambilla E, Redman M, Jain D, Dacic S, Yatabe Y, Tsao MS, Lopez-Rios F, Botling J, Chen G, Chou TY(周德盈), Hirsch FR, Beasley MB, Borczuk A, Bubendorf L, Chung JH, Hwang D, Lin D, Longshore J, Noguchi M, Rekhtman N, Sholl L, Travis W, Yoshida A, Wynes MW, Wistuba II, Kerr KM, Lantuejoul S. The International Association for the Study of Lung Cancer Global Survey on Programmed Death-Ligand 1 Testing for NSCLC. Journal of thoracic oncology 2021;16(4)686-696
  48. Yeh YC, Ho HL, Lin CI, Chou TY(周德盈), Wang YC. Whole-exome Sequencing of Epstein-Barr Virus-associated Pulmonary Carcinoma With Low Lymphocytic Infiltration Shows Molecular Features Similar to Those of Classic Pulmonary Lymphoepithelioma-like Carcinoma: Evidence to Support Grouping Together as One Disease Entity. The American journal of surgical pathology 2021;45(11)1476-1486
  49. Chiang CL, Lee CC, Huang HC, Wu CH, Yeh YC, Shen CI, Luo YH, Shiao TH, Chang HJ, Huang YT, Chen YM, Chou TY(周德盈), Chiu CH. Chiang CL, Lee CC, Huang HC, Wu CH, Yeh YC, Shen CI, Luo YH, Shiao TH, Chang HJ, Huang YT, Chen YM, Chou TY(周德盈), Chiu CH. Targeted oncology 2021;16(2)207-214
  50. Luo YH, Chiu CH, Scott Kuo CH, Chou TY(周德盈), Yeh YC, Hsu HS, Yen SH, Wu YH, Yang JC, Liao BC, Hsia TC, Chen YM. Lung Cancer in Republic of China. 2021;16(4)519-527
  51. Lin SY, Hang JF, Lin YY, Lai CR, Ho HL, Chou TY(周德盈).* Diffuse Intratumoral Stromal Inflammation in Ovarian Clear Cell Carcinoma is Associated With Loss of Mismatch Repair Protein and High PD-L1 Expression. International journal of gynecological pathology 2021;40(1)148-155
  52. Min-Ying Lin, Yu-Chan Chang, Shan-Ying Wang, Muh-Hwa Yang(楊慕華), Chih-Hsien Chang, Michael Hsiao, Richard N Kitsis, Yi-Jang Lee. OncomiR miR-182-5p Enhances Radiosensitivity by Inhibiting the Radiation-Induced Antioxidant Effect through SESN2 in Head and Neck Cancer. Antioxidants (Basel) 2021;10(11)1808
  53. Yi-Ta Hsieh, Hsi-Feng Tu, Muh-Hwa Yang(楊慕華), Yi-Fen Chen, Xiang-Yun Lan, Chien-Ling Huang, Hsin-Ming Chen, Wan-Chun Li. Mitochondrial genome and its regulator TFAM modulates head and neck tumourigenesis through intracellular metabolic reprogramming and activation of oncogenic effectors. Cell Death Dis. 2021;12(11)961
  54. Chih-Cheng Chen, Chia-Chen Hsu, Sung-Lin Chen, Po-Han Lin, Ju-Pei Chen, Yi-Ru Pan, Cih-En Huang, Ying-Ju Chen, Yi-Yang Chen, Yu-Ying Wu, Muh-Hwa Yang(楊慕華). RAS Mediates BET Inhibitor-Endued Repression of Lymphoma Migration and Prognosticates a Novel Proteomics-Based Subgroup of DLBCL through Its Negative Regulator IQGAP3 “Cancers (Basel) 2021;13(9)5024
  55. Hung-Hsi Chen, Hsin-I Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu, Shu-Chun Lin, Muh-Hwa Yang(楊慕華), Woan-Yuh Tarn. DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. iScience. 2021;24(9)103086
  56. Hsin-Kuo Ko, Wen-Kuang Yu, Sheng-Wei Pan, Wei-Chih Chen, Kuang-Yao Yang, Yi-Tsung Lin, Fu-Der Wang, Muh-Hwa Yang(楊慕華), Yuh-Min Chen, Research Center for Epidemic Prevention – National Yang Ming Chiao Tung University (RCEP-NYCU) .Consensus statement and recommendations on the treatment of COVID-19: 2021 update. J Chin Med Assoc. 2021
  57. Pei-Ju Chien, Li-Ting Hung, Ling-Wei Wang, Muh-Hwa Yang(楊慕華), Pen-Yuan Chu. Oncologic results and quality of life in patients with T3 glottic cancer after transoral laser microsurgery. Eur Arch Otorhinolaryngol.2021;278(8)2983-2992
  58. Yi-Ping Hung, Yu-Yun Shao, Chiun Hsu, Chih-Hung Hsu, Jan-Mou Lee, Muh-Hwa Yang(楊慕華), Yee Chao. The unique characteristic in peripheral immune cells in patients with advanced hepatocellular carcinoma. J Formos Med Assoc.2021;120(8)1581-1590
  59. Jeffrey Yung-Chuan Chao, Hsin-Chuan Chang, Jeng-Kai Jiang, Chih-Yung Yang, Fang-Hsin Chen, Yo-Liang Lai, Wen-Jen Lin, Chia-Yang Li, Shu-Chi Wang, Muh-Hwa Yang(楊慕華), Yu-Feng Lin, Wei-Chung Cheng. Using bioinformatics approaches to investigate driver genes and identify BCL7A as a prognostic gene in colorectal cancer. Comput Struct Biotechnol J.2021;19.3922-3929
  60. Tsung-Lun Lee, Pei-Yin Wei, Muh-Hwa Yan(楊慕華), Peter Mu-Hsin Chang, Ling-Wei Wang, Shyh-Kuan Tai. Tongue conservation treatment for oral tongue squamous cell carcinoma with induction chemotherapy, surgery, and risk-adapted adjuvant therapy: A phase II trial. “Cancer Rep (Hoboken)2021;e1456
  61. Tien-Hua Chen, Peter Mu-Hsin Chang, Muh-Hwa Yang(楊慕華). Combination of pembrolizumab and lenvatinib is a potential treatment option for heavily pretreated recurrent and metastatic head and neck cancer. J Chin Med Assoc.2021;84(4)361-367
  62. Hsueh-Ju Lu, Szu-Wen Tseng, Chih-Yu Peng, Hsien-Chun Tseng, Chung-Han Hsin, Hsin-Lin Chen, Wei-Shiou Huang, Ming-Fang Wu, Muh-Hwa Yang(楊慕華), Peter Mu-Hsin Chang. Predictors of early progression after curative resection followed by platinum-based adjuvant chemoradiotherapy in oral cavity squamous cell carcinoma. Postgrad Med.2021;133(3)377-384
  63. Da-Liang Ou, Chia-Wei Chen, Chia-Lang Hsu, Chih-Hung Chung, Zi-Rui Feng, Bin-Shyun Lee, Ann-Lii Cheng, Muh-Hwa Yang(楊慕華), Chiun Hsu. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer.2021;9(3)e001657
  64. Yi-Ping Hung, Yu-Yun Shao, Jan-Mou Lee, Chiun Hsu, Chih-Hung Hsu, Muh-Hwa Yang(楊慕華), Yee Chao. Potential of circulating immune cells as biomarkers of nivolumab treatment efficacy for advanced hepatocellular carcinoma. J Chin Med Assoc.2021;84(2)144-150
  65. Po-Hao Chang, Min-Che Chen, Ya-Ping Tsai, Grace Y T Tan, Pang-Hung Hsu, Yung-Ming Jeng, Yi-Fang Tsai, Muh-Hwa Yang, (楊慕華) Wendy W Hwang-Verslues. Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer. Proc Natl Acad Sci U S A.2021;118(3)e2014408118
  66. Hsiao YJ, Chuang HK, Chi SC, Wang YY, Chiang PH, Teng PC, Kuang TM, Yarmishyn AA, Lin TC, Hwang DK, Chen SJ, Chiou SH(邱士華), Chen MJ, Hsieh AR, Hsu CC. Genome-Wide Polygenic Risk Score for Predicting High Risk Glaucoma Individuals of Han Chinese Ancestry. J Pers Med 2021;11(11)1169
  67. Teng PC, Liang Y, Yarmishyn AA, Hsiao YJ, Lin TY, Lin TW, Teng YC, Yang YP, Wang ML, Chien CS, Luo YH, Chen YM, Hsu PK, Chiou SH(邱士華)*, Chien Y. RNA Modifications and Epigenetics in Modulation of Lung Cancer and Pulmonary Diseases. Int J Mol Sci.2021;22(19)10592
  68. Rastegari E, Hsiao YJ, Lai WY, Lai YH, Yang TC, Chen SJ, Huang PI, Chiou SH(邱士華)*, Mou CY*, Chien Y*An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine. Pharmaceutics.2021;13(7)1067
  69. Cheng HP, Huang CJ, Tsai ML, Ong HT, Cheong SK, Choo KB*, Chiou SH(邱士華)*. MicroRNA-362 negatively and positively regulates SMAD4 expression in TGF-β/SMAD signaling to suppress cell migration and invasion. Int J Med Sci.2021;18(8)1978-1809
  70. Chien CS, Li JY, Chien Y, Wang ML, Yarmishyn AA, Tsai PH, Juan CC, Nguyen P, Cheng HM, Huo TI, Chiou SH(邱士華)*, Chien S*ETTL3-dependent N6-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium. Proc Natl Acad Sci U S A.2021;118(7)e202507018
  71. Jing Guo, Wei-Chung Chiang(姜為中) Mitophagy in aging and longevity. IUBMB Life 2021;Online ahead of print